Katie Boulter will fly the British flag on her own on day six at Wimbledon as she plays Elena Rybakina.
World number one Carlos Alcaraz opens Centre Court for the second successive day as he takes on Chilean Nicolas Jarry.
Elsewhere, last year’s runner-up Ons Jabeur will face former US Open winner Bianca Andreescu and second seed Aryna Sabalenka will be in action.
Here, the PA news agency takes a look at Saturday’s action.
Heavyweights clash early
It was just two years ago that Matteo Berrettini made the final at Wimbledon, but injuries have seen him slide down the rankings.
As a result he was not seeded for this tournament and it meant the prospect of a tricky draw.
And having beaten 15th seed Alex De Minaur in the second round, he now squares off with 19th seed Alexander Zverev.
The German, too, is feeling his way back from a serious injury and in days gone by this match-up would not have been out of place in the latter part of the second week.
With Berrettini serving brilliantly against De Minaur and Zverev not traditionally an outstanding performer at SW19, the Italian could send another seed packing.
Match of the day
Two entertainers will meet on Centre Court as Ons Jabeur takes on Bianca Andreescu in a third-round clash.
Jabeur, last year’s beaten finalist, regularly practises with her Canadian opponent and recently taught her how to play the tweener.
Andreescu is a former US Open champion, but will be playing her third match in three days as she has had to play catch-up with the weather, while Jabeur is well rested after a trouble-free first three matches.
There will be slices, drop shots and possibly tweeners galore as both women eye a place in the second week.
After a chastening afternoon for the British men on Friday, when Cameron Norrie, Andy Murray and Liam Broady all lost within 90 minutes of each other, Katie Boulter is flying the flag for home players in the singles.
She has one of the toughest tests possible as she plays defending champion Elena Rybakina on Centre Court.
The third seed has not exactly been too convincing in her opening two rounds and Boulter will try and feed off a partisan home crowd as she looks to reach the fourth round for the first time.
Order of play
Carlos Alcaraz v Nicolas Jarry
Ons Jabeur v Bianca Andreescu
Katie Boulter v Elena Rybakina
Daniil Medvedev v Martin Fucsovics
Aryna Sabalenka v Anna Blinkova
Alexander Zverev v Matteo Berrettini
Hot and humid with the chance of thundery showers.