With Ireland less than 24 hours away from kick-off in their clash with Italy, there will be a few players who may not sleep too well tonight.
The team that Joe Schmidt has named contains four changes to the starting XV which beat Scotland at Murrayfield two weeks ago and there are further changes among the replacements.
A number of players look set to achieve significant milestones in their international careers at the Stadio Olimpico.
Remarkably, with 67 international appearances to his name, Seán Cronin will only be making his first Six Nations start against Italy tomorrow.
There are also first Six Nations starts in the pack with Dave Kilcoyne and Ultan Dillane set to achieve that feat.
On the bench, there could be an Ireland debut for Connacht’s Jack Carty and Schmidt has been impressed with the out half’s ability to learn in training.
“Jack is impossible to ruffle. We tried to put a bit of pressure on him in training, it doesn’t mean that it’s all been seamless and gone perfectly but if something does go wrong, he gets it right the next time,” Schmidt said.
“His ability to absorb information, to slot into the team, all those things have been really first rate and again, he went back to Connacht last week and I thought he was really good for them.”
If Carty does enter the fray as expected in the second half against Italy on Sunday, he will be among familiar company.
This Six Nations squad contains a much stronger Connacht contingent than we have seen in recent years with Bundee Aki, Dillane and Roux all named to start for tomorrow’s clash.