Eddie Jones has made three changes to the starting XV which lost to Scotland at Murrayfield almost two weeks ago for the trip to Paris this weekend to take on France.
The biggest omission is that of Dylan Hartley, who is ruled out of the game through injury so Jamie George comes straight into the team in his absence.
Elliot Daly comes in on the left wing with Anthony Watson switching to full-back at the expense of Mike Brown. Jonny May switches to the right wing to accommodate both Watson and Daly.
Ben Te’o comes back into the starting team at outside centre at the expense of Jonathan Joseph. Due to Hartley’s absence, Owen Farrell will captain the side.
There are six changes in the replacements which include Luke Cowan-Dickie (Exeter Chiefs), Mike Brown (Harlequins), James Haskell (Wasps), Jonathan Joseph (Bath Rugby), Sam Simmonds (Exeter Chiefs) and Kyle Sinckler (Harlequins).
Head coach Eddie Jones said: “This game is about the opportunity for the team to move forward and we want a response from the players this week.
“Against France, we want to be brutal and aggressive on the gain line and to play with a great tactical discipline.”
On Farrell captaining the side Jones said: “Owen will be very proud to be captain but at the same time he is disappointed for Dylan to miss out through injury and he knows the position of captain carries a lot of responsibility.”
Jones added on the vice-captaincy going to Vunipola: “We need to make sure we have one strong voice among the forward leaders and Mako has been doing some great work behind the scenes and will step up and take that on officially against France.”
15 Anthony Watson (Bath Rugby 31 caps)
14 Jonny May (Leicester Tigers 32 caps)
13 Ben Te’o (Worcester Warriors 11 caps)
12 Owen Farrell (Saracens 56 caps) C
11 Elliot Daly (Wasps 16 caps)
10 George Ford (Leicester Tigers 43 caps)
9 Danny Care (Harlequins 79 caps)
1 Mako Vunipola (Saracens 47 caps) VC
2 Jamie George (Saracens 23 caps)
3 Dan Cole (Leicester Tigers 80 caps)
4 Joe Launchbury (Wasps 50 caps)
5 Maro Itoje (Saracens 17 caps)
6 Courtney Lawes (Northampton Saints 64 caps)
7 Chris Robshaw (Harlequins 62 caps)
8 Nathan Hughes (Wasps 13 caps)
16 Luke Cowan-Dickie (Exeter Chiefs 4 caps)
17 Joe Marler (Harlequins 54 caps)
18 Kyle Sinckler (Harlequins 8 caps)
19 James Haskell (Wasps 75 caps)
20 Sam Simmonds (Exeter Chiefs 5 caps)
21 Richard Wigglesworth (Saracens 29 caps)
22 Jonathan Joseph (Bath Rugby 38 caps)
23 Mike Brown (Harlequins 67 caps)
The Ireland vs England Legends game can be watched for free exclusively on Pundit Arena TV.
WHEN: Friday, 16th March 2018, 19:30
WHERE: Twickenham Stoop, London, UK
WATCH: Pundit Arena TV